The diagnosis is usually made by a dermatologist after reviewing the presentation of the individual, through a combination of history and physical findings (clinical diagnosis).
A history of previous trauma to the scalp, supported by physical findings of open wounds, crusts and scarring alopecia in the presence of thin skin and significant sun damage of the scalp, is usually indicative of EPDS.
Tissue sampling (skin biopsy) only serves to confirm the diagnosis of EPDS in the presence of positive history and clinical findings.
In some cases, a tissue biopsy may be taken to exclude other serious conditions that may mimic the presentation of EPDS: